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Therefore, it mimics a variety of diseases and requires a high index of suspicion. TB in bones outside the spine may also compress adjacent nerves. The usual site of TB is the lungs (pulmonary TB), but other organs can be involved. During the physical examination, diffuse lymphadenopathy and hepatosplenomegaly may be noted. In the absence of coexisting immunocompromised state and lack of specific symptoms a reactivation of treated mycobacterial tuberculosis (MTB) infection is generally not considered in the differential diagnosis of leg pain. Discussion. ... Called disseminated histoplasmosis, it can affect nearly any part of your body, including your mouth, liver, central nervous system, skin and adrenal glands. About 10% of latent infections progress to active disease which, if left untreated, kills about half of those affected. Liver infection is common in patients with advanced pulmonary TB and widely disseminated or miliary TB. This is a very unusual presentation of a 41-year-old female with disseminated TB. Tuberculosis (TB) is a contagious infection that usually attacks your lungs. The only sign of TB infection is a positive reaction to the tuberculin skin test or TB blood test. Spinal Deformity. Miliary tuberculosis is a form of tuberculosis that is characterized by a wide dissemination into the human body and by the tiny size of the lesions (1–5 mm). Tuberculosis generally affects the lungs, but can also affect other parts of the body. Disseminated TB such as TB meningitis particularly occurs in young children less than 3 years old. Primary vs Secondary Tuberculosis Tuberculosis or TB is caused by the bacterial group mycobacterium. Tuberculosis is a contagious infection caused by the airborne bacteria Mycobacterium tuberculosis. Disseminated tuberculosis can affect many different body areas. When a person develops active TB disease, the symptoms (such as cough, fever, night sweats, or weight loss) may be mild for many months. Disseminated TB develops in the small number of infected people whose immune systems do not successfully contain the primary infection. Around 90 percent of cases involve multiple organs and have a nearly 100 percent risk of death if left untreated. Disseminated TB is often missed antemortem and has been confirmed in 33 to 80 percent of autopsies. Disseminated TB is defined as tuberculous infection involving the blood stream, bone marrow, liver, or 2 or more noncontiguous sites, or miliary TB 2,22. 1 In patients, without HIV infection >80% of TB cases are pulmonary in nature and rest are disseminated. Cutaneous tuberculosis (TB) is essentially an invasion of the skin by Mycobacterium tuberculosis, the same bacteria that cause TB of the lungs (pulmonary TB). Latent TB, also called inactive TB or TB infection, isn't contagious. The symptoms are nonspecific and the duration of symptoms before diagnosis is variable7,16,18,20,22,26. Treatment of disseminated TB involves a combination of several medicines (usually 4). In the United States, most people with primary tuberculosis get better and have no further evidence of disease. The symptoms are nonspecific and the duration of symptoms before diagnosis is variable 7,16,18,20,22,26. Latent TB. Cutaneous TB is a relatively uncommon form of extrapulmonary TB (TB infection of other organs and tissues). For example, pulmonary MAC mainly affects the lungs; disseminated MAC affects the whole body; and MAC lymphadenitis causes swollen lymph nodes. The goal of treatment is to cure the infection with medicines that fight the TB bacteria. The symptoms of pulmonary MAC infection start slowly, get worse over time and may last for weeks to months. Dear Editor, Tuberculosis (TB) remains a leading problem in public health in many parts of the world, mainly due to poor living conditions and increasing incidence of patients with human immunodeficiency virus (HIV) infection. However, the liver generally heals without sequelae when the principal infection is treated. Symptoms of miliary tuberculosis can be vague and difficult to identify. If untreated, disseminated histoplasmosis is usually fatal. Disseminated TB is defined as tuberculous infection involving the blood stream, bone marrow, liver, or two or more noncontiguous sites, or miliary TB . Synonym(s): disseminated tuberculosis , generalized tuberculosis She initially pre-sented to her general practitioner with cough, of acute onset which started 10 days back, and was dry in nature. Classic miliary TB is defined as milletlike (mean, 2 mm; range, 1-5 mm) seeding of TB bacilli in the lung, as evidenced on chest radiography. These symptoms resolved with increasing the prednisolone dose, followed by gradual tapering of steroid treatment. The following factors can increase the rate of TB infection in a population: Increase in HIV infections; Increase in number of homeless people with unstable housing (poor environment and nutrition) The appearance of drug-resistant strains of TB; Symptoms. The symptoms of chronic histoplasmosis sometimes mimic those of tuberculosis. Treatment. In this condition, you have a TB infection, but the bacteria remain in your body in an inactive state and cause no symptoms. Its name comes from a distinctive pattern seen on a chest radiograph of many tiny spots distributed throughout the lung fields with the appearance similar to millet seeds—thus the term "miliary" tuberculosis. BCG is a live vaccine prepared from attenuated strains of M bovis. TB is much more aggressive in immunocompromised patients and, if not appropriately and aggressively treated, may be fatal in as little as 2 mo from a patient's initial presentation, especially with MDR-TB. It can turn into active TB, so treatment is important for the person with latent TB and to help control the spread of TB. Persons with latent TB infection do not feel sick and do not have any symptoms. Infants and young children are at particular risk of developing severe, disseminated and often lethal disease, which may show itself as TB meningitis or miliary TB. Symptoms of TB disease in other parts of the body depend on the area affected. Persons with latent TB infection are not infectious and cannot spread TB infection to others. Disseminated TB is defined as tuberculous infection involving the blood stream, bone marrow, liver, or 2 or more noncontiguous sites, or miliary TB2,22. Pulmonary tuberculosis (TB) is a serious bacterial infection of the lungs. Symptoms depend on the affected areas of the body and can include: Abdominal pain or swelling Chills Cough and shortness of breath Fatigue Fever General discomfort, uneasiness, or … If spinal TB destroys vertebrae and discs, the spine can lose its normal shape. The patient related her symptoms to the recent house move and possibly allergic in nature. Definition: Disseminated tuberculosis is a contagious mycobacterial infection in which mycobacteria have spread from the lungs to other parts of the body through the blood or lymph system.. Disseminated BCG disease is a rare but life-threatening complication of BCG administration. You may need to take many different pills for 6 months or longer. Disseminated tuberculosis (TB) occurs when the contagious bacterium spreads from the lungs to other organs through the bloodstream or lymphatic system. Infants, young children, and immunocompromised children (e.g., children with HIV) are at the highest risk of developing the most severe forms of TB such as TB meningitis or disseminated TB disease. They are infected with M. tuberculosis, but do not have TB disease. Miliary TB, or disseminated tuberculosis, is a potentially life-threatening form of the infection in which large numbers of TB bacteria spread all over the body through the bloodstream. It is mainly a respiratory tract infection, but can act as an opportunistic infection and a systemic infection in times of reduced or absent immunity. Disseminated tuberculosis represents the multi-site disease caused by Mycobacterium tuberculosis after it has migrated from the primary site of infection to multiple locations. Active TB primarily develops in the lungs in adults, but may also affect other areas of the body. 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