The effects and side effects of its long-term use are unknown. What Does Matrixyl Do For Skin? It is known to be one of the most effective anti aging ingredients, for use in anti-aging creams, in the world, today. However, the price does not … No research has been … It can be applied freely, without fear on all parts of the body, because, side effects … Learn about the benefits and side effects of active ingredients in anti-aging beauty products including Matrixyl Synthe'6 from Truth In Aging experts. There is a large price variation between different products containing Matrixyl 3000, although none are dirt-cheap. Free shipping on all domestic orders … The proponents claim that palmitoyl pentapeptide-4 is at least as effective against wrinkles as retinol but does not cause skin irritation, which is a common side-effect … Matrixyl promises to fight wrinkles as well, if not better, than retinol (the gold standard for anti-aging) – and without its irritating side effects, too.Does it deliver? This is a tricky … Some of the major points of effectiveness and advantages of Matrixyl 3000 are given below: 1. Potential Side Effects of Matrixyl (Palmitoyl Pentapeptide-4) The EWG gives Palmitoyl Pentapeptide-four a zero rating based totally on one hundred% records hole. Please note that Matrixyl is distinct from its similar sounding distant cousin Matrixyl 3000.